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Article

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.

Immunity - 1 Jul 1998

Frey S, Bertocci B, Delbos F, Quint L, Weill J C, Reynaud C A

Abstract excerpt

Primary responses to the hapten phenyloxazolone and chronic responses to environmental antigens occurring in Peyer's patches were analyzed in two different mismatch repair-deficient backgrounds. Paradoxically, whereas primary responses were found normal in MSH2- and only slightly diminished in PMS2-deficient mice, mutations in Peyer's patch B cells from both k.o. animals were reduced three times, the subset of...

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Source

Identifiers

PMID: 9697842
DOI: 10.1016/s1074-7613(00)80594-4

Genes

MSH2
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.PMID 9697842Read ↗

PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.Semantic proximity Read ↗

Mismatch repair co-opted by hypermutation.Semantic proximity Read ↗

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.Semantic proximity Read ↗

Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Semantic proximity Read ↗

Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes.Semantic proximity Read ↗

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.Semantic proximity Read ↗

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.Semantic proximity Read ↗

Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide.Semantic proximity Read ↗

Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair ProteinSemantic proximity Read ↗

Severe Attenuation of the B Cell Immune Response in Msh2-deficient MiceSemantic proximity Read ↗

Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.Semantic proximity Read ↗

Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.Semantic proximity Read ↗

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