Article
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.
Immunity - 1 Jul 1998
Frey S, Bertocci B, Delbos F, Quint L, Weill J C, Reynaud C A
Abstract excerpt
Primary responses to the hapten phenyloxazolone and chronic responses to environmental antigens occurring in Peyer's patches were analyzed in two different mismatch repair-deficient backgrounds. Paradoxically, whereas primary responses were found normal in MSH2- and only slightly diminished in PM...
Topics
- Adenosine Triphosphatases
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Line
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Genes, Immunoglobulin
- Germinal Center
- Haptens
- Mice
- Mice, Knockout
- Microsatellite Repeats
- Mismatch Repair Endonuclease PMS2
- Molecular Sequence Data
- MutS Homolog 2 Protein
- Mutation