Pseudoprimers cause somatic hypermutation of Ig genes.

Article

Pseudoprimers cause somatic hypermutation of Ig genes.

Biochemistry. Biokhimiia - 1 Dec 1998

Olovnikov A M

Abstract excerpt

It is proposed that hypermutation of the Ig gene is based on the use of "misprimers" (MPs) capable of competing with a true primer for the DNA. The MP is a product of the cleavage of the nascent transcript. Each MP has an erroneous base on its 3; terminus. Wobbling of the unpaired 3; end of the M...

Topics

Animals
DNA Primers
Genes, Immunoglobulin
Humans
Mutation
Pseudogenes

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.