Article
NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1998
Kurago Z B, Lutz C T, Smith K D, Colonna M
Abstract excerpt
DX9 mAb-binding killer cell-inhibitory receptors (KIR) recognize HLA-B molecules that express the Bw4 public serologic epitope. We assessed DX9+ NK cell fine specificity recognition of HLA-B7 variants and HLA-B27 alleles by 51Cr release natural cytotoxicity assays and by flow cytometry and enzyme...
Topics
- Alleles
- Antibodies, Monoclonal
- Cell Line
- Clone Cells
- Cytotoxicity Tests, Immunologic
- Cytotoxicity, Immunologic
- Epitopes
- Genetic Variation
- HLA-B Antigens
- HLA-B7 Antigen
- Humans
- Immunity, Innate
- Interferon-gamma
- Killer Cells, Natural
- Receptors, Immunologic
- Receptors, KIR