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Article

NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1998

Kurago Z B, Lutz C T, Smith K D, Colonna M

Abstract excerpt

DX9 mAb-binding killer cell-inhibitory receptors (KIR) recognize HLA-B molecules that express the Bw4 public serologic epitope. We assessed DX9+ NK cell fine specificity recognition of HLA-B7 variants and HLA-B27 alleles by 51Cr release natural cytotoxicity assays and by flow cytometry and enzyme-linked immunospot (ELISPOT) IFN-gamma synthesis and release assays. 721.221 target cell expression of Bw4+ HLA-B27...

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PMID: 9469412

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