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Article

KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jul 2016

Forlenza Christopher J, Boudreau Jeanette E, Zheng Junting, Le Luduec Jean-Benoît, Chamberlain Elizabeth, Heller Glenn, Cheung Nai-Kong V, Hsu Katharine C

Abstract excerpt

PURPOSE: In patients with neuroblastoma (NB), treatment with anti-GD2 monoclonal antibody (mAb) directs natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) against tumor cells. However, tumor cytotoxicity is attenuated by ligation of inhibitory killer immunoglobulin-like receptors (KIRs) by HLA class I molecules. KIR3DL1 polymorphism influences its ability to engage HLA-Bw4 ligands....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27069083
DOI: 10.1200/JCO.2015.64.9558
PMCID: PMC4962735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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