Article
Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2001
Gardiner C M, Guethlein L A, Shilling H G, Pando M, Carr W H, Rajalingam R, Vilches C, Parham P
Abstract excerpt
KIR3DL1 and KIR3DL2 are NK cell receptors for polymorphic HLA-B and -A determinants. The proportion of NK cells that bind anti-KIR3DL1-specific Ab DX9 and their level of binding vary between individuals. To determine whether these differences are due to KIR polymorphism, we assessed KIR3D gene diversity in unrelated individuals and families. Both KIR3DL1 and KIR3DL2 are highly polymorphic genes, with KIR3DS1...
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