Article
Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.
American journal of human genetics - 1 Aug 1994
Caron H, van Sluis P, van Roy N, de Kraker J, Speleman F, Voûte P A, Westerveld A, Slater R, Versteeg R
Abstract excerpt
Neuroblastomas often show loss of heterozygosity of the chromosomal region 1p36 (LOH 1p), probably reflecting loss of a tumor-suppressor gene. Here we describe three neuroblastoma tumors and two cell lines in which LOH 1p results from an unbalanced translocation between the p arm of chromosome 1...
Topics
- Alleles
- Blotting, Southern
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 17
- G2 Phase
- Gene Deletion
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- In Situ Hybridization, Fluorescence
- Karyotyping
- Mitosis
- Neuroblastoma
- S Phase