Article
Activating point mutations of the gsp oncogene in human thyroid adenomas.
Molecular carcinogenesis - 1 Jan 1991
O'Sullivan C, Barton C M, Staddon S L, Brown C L, Lemoine N R
Abstract excerpt
The gene for the alpha polypeptide chain (alpha s) of the heterotrimeric G protein Gs can be activated to the putative oncogene gsp by specific point mutations at codons 201 and 227. Such mutations have been reported in 40% of human growth hormone-secreting pituitary adenomas and in a single autonomously functioning thyroid adenoma. We examined an archival series of 45 differentiated human thyroid tumors by...
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