Article
Activating point mutations of the gsp oncogene in human thyroid adenomas.
Molecular carcinogenesis - 1 Jan 1991
O'Sullivan C, Barton C M, Staddon S L, Brown C L, Lemoine N R
Abstract excerpt
The gene for the alpha polypeptide chain (alpha s) of the heterotrimeric G protein Gs can be activated to the putative oncogene gsp by specific point mutations at codons 201 and 227. Such mutations have been reported in 40% of human growth hormone-secreting pituitary adenomas and in a single auto...
Topics
- Adenoma
- Alleles
- Base Sequence
- DNA Mutational Analysis
- DNA, Neoplasm
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Oligonucleotide Probes
- Oligonucleotides
- Oncogenes
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Thyroid Neoplasms