Article
G protein and thyrotropin receptor mutations in thyroid neoplasia.
The Journal of clinical endocrinology and metabolism - 1 Feb 1997
Esapa C, Foster S, Johnson S, Jameson J L, Kendall-Taylor P, Harris P E
Abstract excerpt
The cAMP pathway plays a central role in thyroid follicular cell growth and function. Mutations of the TSH receptor (TSHR) or G proteins (gsp) that activate adenylyl cyclase have been identified in autonomously functioning thyroid nodules. Gsp mutations have been identified also in other forms of...
Topics
- Amino Acid Sequence
- Codon
- GTP-Binding Proteins
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptors, Thyrotropin
- Thyroid Neoplasms