Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas from Brazil.

Thyroid : official journal of the American Thyroid Association - 1 Nov 1999

Nogueira C R, Kopp P, Arseven O K, Santos C L, Jameson J L, Medeiros-Neto G

Abstract excerpt

Constitutively activating mutations in the thyrotropin (TSH) receptor have been identified as a major molecular cause of hyperfunctioning thyroid adenomas. A smaller subset of these benign tumors is caused by constitutive activation of the adenylyl cyclase cascade by somatic mutations in the Gsalpha gene. In this study, we analyzed hyperfunctioning thyroid adenomas from seven Brazilian patients for TSH receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Luciferases

Share to Mutation

Share to Receptors, Thyrotropin

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 10595453
DOI: 10.1089/thy.1999.9.1063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas from Brazil.PMID 10595453Read ↗

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.Semantic proximity Read ↗

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.Semantic proximity Read ↗

Autonomously functioning thyroid nodules in a former iodine-deficient area commonly harbor gain-of-function mutations in the thyrotropin signaling pathway.Semantic proximity Read ↗

Gs alpha mutations in hyperfunctioning thyroid adenomas.Semantic proximity Read ↗

Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.Semantic proximity Read ↗

Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.Semantic proximity Read ↗

Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas.Semantic proximity Read ↗

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.Semantic proximity Read ↗

Genetic alterations in thyroid hyperfunctioning adenomas.Semantic proximity Read ↗

Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan.Semantic proximity Read ↗

Non-hyperfunctioning nodules from multinodular goiters: a minor role in pathogenesis for somatic activating mutations in the TSH-receptor and Gsalpha subunit genes.Semantic proximity Read ↗

Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.