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Article

[Resistance of cytomegalovirus to ganciclovir: rapid detection of the mutations 460 of the UL97 phosphotransferase].

Pathologie-biologie - 1 May 1996

Alain S, Mazeron M C, Vadam C, Honderlick P, Thouvenot D, Freymuth F, Fillet A M, Carquin J, Sanson-Le Pors M J

Abstract excerpt

The substitution of methionine by either isoleucine or valine at residue 460 in the UL97 phosphotransferase has been shown to be responsible for resistance to ganciclovir (GCV) in 30% of resistant cytomegalovirus (CMV) isolates [4]. These substitutions require one nucleotide change in the gene (G- > T 1 380 and A- > G 1378 respectively). The aim of this study was to develop a discriminative PCR assay for rapid...

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PMID: 8758494

Genes

RCL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Resistance of cytomegalovirus to ganciclovir: rapid detection of the mutations 460 of the UL97 phosphotransferase].PMID 8758494Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

Cytomegalovirus UL97 mutations associated with ganciclovir resistance in immunocompromised patients from Argentina.Semantic proximity Read ↗

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Rapid detection by reverse hybridization of mutations in the UL97 gene of human cytomegalovirus conferring resistance to ganciclovir.Semantic proximity Read ↗

[Presence of mutations associated with ganciclovir resistance in cytomegalovirus UL97 gene].Semantic proximity Read ↗

Frequency of UL97 Phosphotransferase Mutations Related to Ganciclovir Resistance in Clinical Cytomegalovirus IsolatesSemantic proximity Read ↗

Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.Semantic proximity Read ↗

A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.Semantic proximity Read ↗

Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir.Semantic proximity Read ↗

HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil.Semantic proximity Read ↗

Genotypic characterization of human cytomegalovirus UL97 phosphotransferase natural polymorphism in the era of ganciclovir and maribavir.Semantic proximity Read ↗

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity.Semantic proximity Read ↗

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