Article
Homology modeling of Neurospora crassa geranylgeranyl pyrophosphate synthase: structural interpretation of mutant phenotypes.
Protein engineering - 1 Sept 1997
Quondam M, Barbato C, Pickford A, Helmer-Citterich M, Macino G
Abstract excerpt
A model of the tertiary structure of the Neurospora crassa carotenogenic prenyltransferase, geranylgeranyl pyrophosphate synthase (GGPPS), is presented, based on structural homology with other prenyltransferases and on the crystal structure of recombinant avian farnesyl pyrophosphate synthase (FP...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Crystallography, X-Ray
- Geranylgeranyl-Diphosphate Geranylgeranyltransferase
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Neurospora crassa
- Oxidoreductases
- Phenotype
- Point Mutation
- Protein Conformation
- Protein Structure, Secondary
- Recombinant Proteins
- Sequence Alignment
- Sequence Homology, Amino Acid
- Software