Article
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase.
Insect biochemistry and molecular biology - 1 Oct 2009
Vandermoten Sophie, Santini Sébastien, Haubruge Eric, Heuze Fabien, Francis Frédéric, Brasseur Robert, Cusson Michel, Charloteaux Benoit
Abstract excerpt
In addition to providing lipid chains for protein prenylation, short-chain isoprenyl diphosphate synthases (scIPPSs) play a pivotal role in the biosynthesis of numerous mevalonate pathway end-products, including insect juvenile hormone and terpenoid pheromones. For this reason, they are being considered as targets for pesticide development. Recently, we characterized an aphid scIPPS displaying dual geranyl...
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