Article
Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae.
The Journal of biological chemistry - 30 Apr 1999
Hernando Y, Carter A T, Parr A, Hove-Jensen B, Schweizer M
Abstract excerpt
The PRS gene family in Saccharomyces cerevisiae consists of five genes each capable of encoding a 5-phosphoribosyl-1(alpha)-pyrophosphate synthetase polypeptide. To gain insight into the functional organization of this gene family we have constructed a collection of strains containing all possible combinations of disruptions in the five PRS genes. Phenotypically these deletant strains can be classified into three...
Topics
- Gene Deletion
- Genes, Lethal
- Phenotype
- Phosphoribosyl Pyrophosphate
- Recombinant Proteins
- Saccharomyces cerevisiae
- Transcription, Genetic