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Article

The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor

16 Feb 1998

Abstract excerpt

The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4, we disrupted the CRFB4 gene in mice by means of homologous...

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PMID: 9463407
DOI: 10.1084/jem.187.4.571

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