Article
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.
The EMBO journal - 16 Oct 1995
Lutfalla G, Holland S J, Cinato E, Monneron D, Reboul J, Rogers N C, Smith J M, Stark G R, Gardiner K, Mogensen K E
Abstract excerpt
The cellular receptor for the alpha/beta interferons contains at least two components that interact with interferon. The ifnar1 component is well characterized and a putative ifnar2 cDNA has recently been identified. We have cloned the gene for ifnar2 and show that it produces four different tran...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cell Line
- Chromosomes, Human, Pair 21
- Cloning, Molecular
- DNA Probes
- DNA, Complementary
- Gene Expression
- Genetic Complementation Test
- Humans
- Interferon-alpha