Article
The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
Science (New York, N.Y.) - 13 Feb 1998
den Haan J M, Meadows L M, Wang W, Pool J, Blokland E, Bishop T L, Reinhardus C, Shabanowitz J, Offringa R, Hunt D F, Engelhard V H, Goulmy E
Abstract excerpt
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from...
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