Article
Molecular modeling of the minor histocompatibility antigen HA-1 peptides binding to HLA-A alleles.
Tissue antigens - 1 Jan 2000
Ren E C, Kangueane P, Kolatkar P, Lin M T, Tseng L H, Hansen J A
Abstract excerpt
Mismatch of the minor histocompatibility antigen HA-1 has been shown to correlate with graft-versus-host disease in HLA-matched sibling marrow transplants. The HA-1H peptide (VLHDDLLEA) that generates this response is known to be presented by HLA-A*0201. In order to understand the interaction of HA-1 peptides with other HLA-A alleles, we have used the LOOK interface to construct molecular models of both HA-1H...
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