Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin.

Nature neuroscience - 1 Jan 2006

Hiramoto Masaki, Hiromi Yasushi

Abstract excerpt

Networks in the CNS consist of neural modules that are connected in a repetitive array. Whereas individual modules contain guidance information along which axons track within the unit, these guidance cues hinder axon extension across module boundaries. We investigated how axons solve this 'boundary problem' by analyzing the longitudinal connections of neuromeres in Drosophila melanogaster. The initial trajectory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Fluorescent Antibody Technique
Share to Nerve Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Net

Share to Netrin-1

Share to Receptors, Cell Surface

Share to Receptors, Immunologic

Share to Roundabout Proteins

Source

Identifiers

PMID: 16341212
DOI: 10.1038/nn1612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin.PMID 16341212Read ↗

Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS.Semantic proximity Read ↗

Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

Axon guidance at the midline choice point.Semantic proximity Read ↗

Axon sorting within the spinal cord marginal zone via Robo-mediated inhibition of N-cadherin controls spinocerebellar tract formation.Semantic proximity Read ↗

Interaxonal interaction defines tiled presynaptic innervation in C. elegans.Semantic proximity Read ↗

To cross or not to cross: a genetic analysis of guidance at the midline.Semantic proximity Read ↗

Glia dictate pioneer axon trajectories in the Drosophila embryonic CNS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.