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Article

Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells.

International journal of cancer - 30 Jan 1998

Martinez-Lorenzo M J, Gamen S, Etxeberria J, Lasierra P, Larrad L, Piñeiro A, Anel A, Naval J, Alava M A

Abstract excerpt

Apoptosis induced by effector cells of the immune system or by cytotoxic drugs is a main mechanism mediating the prevention or elimination of tumoral cells. For instance, the human T-cell leukemia Jurkat is sensitive to Fas-induced apoptosis and to activation-induced cell death (AICD), and the promonocytic leukemia U937 is sensitive to Fas- and TNF-induced apoptosis. In this work, we have analyzed the mechanisms...

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Identifiers

PMID: 9455811
DOI: 10.1002/(sici)1097-0215(19980130)75:3<473::aid-ijc23>3.0.co;2-8

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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