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Article

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.

Blood - 15 Feb 2007

Bosque Alberto, Aguiló Juan Ignacio, Alava M Angeles, Paz-Artal Estela, Naval Javier, Allende Luis M, Anel Alberto

Abstract excerpt

The BH3-only protein Bim is required for maintaining the homeostasis of the immune system, since Bim regulates the down-modulation of T-cell responses, mainly through cytokine deprivation. Using T-cell blasts from healthy donors and also from patients with autoimmune lymphoproliferative syndromes (ALPSs) due to homozygous loss-of-function mutation of FasL (ALPS-Ic) or heterozygous mutation in the Fas/CD95 death...

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Identifiers

PMID: 17062728
DOI: 10.1182/blood-2006-05-022319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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