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Article

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

Genes & development - 15 Mar 1998

Woo M, Hakem R, Soengas M S, Duncan G S, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman S A, Senaldi G, Howard T, Lowe S W, Mak T W

Abstract excerpt

Caspases are fundamental components of the mammalian apoptotic machinery, but the precise contribution of individual caspases is controversial. CPP32 (caspase 3) is a prototypical caspase that becomes activated during apoptosis. In this study, we took a comprehensive approach to examining the role of CPP32 in apoptosis using mice, embryonic stem (ES) cells, and mouse embryonic fibroblasts (MEFs) deficient for...

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Identifiers

PMID: 9512515
DOI: 10.1101/gad.12.6.806
PMCID: PMC316633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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