Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Daunorubicin- and Ara-C-induced interphasic apoptosis of human type II leukemia cells is caspase-8-independent.

Biochimica et biophysica acta - 10 Oct 2002

Terrisse Anne-Dominique, Bezombes Christine, Lerouge Sandra, Laurent Guy, Jaffrézou Jean-Pierre

Abstract excerpt

Drug-induced interphasic apoptosis in human leukemia cells is mediated through intracellular signaling pathways, of which the most proximal (initiating) event remains unclear. Indeed, both early ceramide generation and procaspase-8 cleavage have been individually identified as the initial apoptotic signaling events which precede the mitochondrial control of the apoptotic execution phase in Type II cells. In order...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 8
Share to Caspase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ceramides

Share to Cytarabine

Share to Daunorubicin

Share to Fas-Associated Death Domain Protein

Share to Interphase

Share to Jurkat Cells

Source

Identifiers

PMID: 12385892
DOI: 10.1016/s1388-1981(02)00297-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Daunorubicin- and Ara-C-induced interphasic apoptosis of human type II leukemia cells is caspase-8-independent.PMID 12385892Read ↗

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis.Semantic proximity Read ↗

Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells.Semantic proximity Read ↗

A new four-color flow cytometric assay to detect apoptosis in lymphocyte subsets of cultured peripheral blood cellsSemantic proximity Read ↗

Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondriaSemantic proximity Read ↗

Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondriaSemantic proximity Read ↗

Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.Semantic proximity Read ↗

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis.Semantic proximity Read ↗

Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.Semantic proximity Read ↗

Differential Induction of Apoptosis by Fludarabine Monophosphate in Leukemic B and Normal T Cells in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

[Establishment and characterization of rat myelomonocytic leukemia clones undergoing differentiation or apoptosis].Semantic proximity Read ↗

Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosisSemantic proximity Read ↗

Switching leukemia cell phenotype between life and death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.