Loss of imprinting in hepatoblastoma.

Article

Loss of imprinting in hepatoblastoma.

Cancer research - 1 May 1995

Rainier S, Dobry C J, Feinberg A P

Abstract excerpt

We and others have described loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subseq...

Topics

Alleles
Child
Down-Regulation
Gene Expression Regulation, Neoplastic
Genomic Imprinting
Hepatoblastoma
Humans
Insulin-Like Growth Factor II
Liver Neoplasms
Polymorphism, Genetic

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