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Article

Loss of imprinting in hepatoblastoma.

Cancer research - 1 May 1995

Rainier S, Dobry C J, Feinberg A P

Abstract excerpt

We and others have described loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that LOI is a general...

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Source

Identifiers

PMID: 7728748

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Loss of imprinting in hepatoblastoma.PMID 7728748Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

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IGF2 but not H19 shows loss of imprinting in human glioma.Semantic proximity Read ↗

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Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms TumorSemantic proximity Read ↗

Genomic imprinting and carcinogenesis.Semantic proximity Read ↗

Loss of imprinting of the IGF2 gene in a Wilms' tumor in an adult.Semantic proximity Read ↗

Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.Semantic proximity Read ↗

Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma.Semantic proximity Read ↗

[The aberrant imprinting of insulin-like growth factor II and H19 in human hepatocellular carcinoma].Semantic proximity Read ↗

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourSemantic proximity Read ↗

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