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Article

Functional analysis of aortic endothelial cells expressing mutant PDGF receptors with respect to expression of matrix metalloproteinase-3.

Biochemical and biophysical research communications - 7 Jun 2002

Kanaki Tatsuro, Bujo Hideaki, Mori Seijiro, Yanjuan Zhu, Takahashi Kazuo, Yokote Koutaro, Morisaki Nobuhiro, Saito Yasushi

Abstract excerpt

Platelet-derived growth factor (PDGF) stimulates expression of matrix metalloproteinases (MMPs), including stromelysin-1 (MMP-3). Induction of these expressions is known to occur during the course of atherosclerosis, tumor invasion, and metastasis. We investigated PDGF-alpha receptor (alphaR)- and beta receptor (betaR)-mediated signaling pathways for the expression of MMP-3 and invasion activity using porcine...

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Identifiers

PMID: 12051699
DOI: 10.1016/S0006-291X(02)00468-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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