Article
Polypyrrole DNA chip on a silicon device: example of hepatitis C virus genotyping.
Analytical biochemistry - 15 Jan 1998
Livache T, Fouque B, Roget A, Marchand J, Bidan G, Téoule R, Mathis G
Abstract excerpt
We describe in this article an oligonucleotide array constructed on a silicon device bearing a matrix of addressable 50-microns microelectrodes. Each electrode was covered by a conducting polymer (polypyrrole) grafted by an oligonucleotide (ODN). The DNA chip was prepared by successive electrochemically addressed copolymerizations of 5' pyrrole-labeled ODN and pyrrole. Following hybridization of the biotinylated...
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