Preparation of a DNA matrix via an electrochemically directed copolymerization of pyrrole and oligonucleotides bearing a pyrrole group.

doi:10.1093/nar/22.15.2915

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Article

Preparation of a DNA matrix via an electrochemically directed copolymerization of pyrrole and oligonucleotides bearing a pyrrole group.

Nucleic acids research - 11 Aug 1994

Livache T, Roget A, Dejean E, Barthet C, Bidan G, Téoule R

Abstract excerpt

A new methodology for the preparation of addressed DNA matrices is described. The process includes an electrochemically directed copolymerization of pyrrole and oligonucleotides bearing on their 5' end a pyrrole moiety introduced by phosphoramidite chemistry. The electro-controlled synthesis of the copolymer (poly-pyrrole) gives, in one step, a solid conducting film deposited on the surface of an electrode. The...

Topics

Amides
Base Sequence
DNA
Electrochemistry
Electrodes
Genes, ras
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Oligonucleotides
Phosphoric Acids

Polymers

Pyrroles

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