Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels.

Abstract excerpt

A functional kinetic model is developed to describe the activation gating process of the Shaker potassium channel. The modeling in this paper is constrained by measurements described in the preceding two papers, including macroscopic ionic and gating currents and single channel ionic currents. These data were obtained from the normally activating wild-type channel as well as a mutant channel V2, in which the...

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