Article
Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions.
The Journal of general physiology - 1 Feb 1998
Schoppa N E, Sigworth F J
Abstract excerpt
The conformational changes associated with activation gating in Shaker potassium channels are functionally characterized in patch-clamp recordings made from Xenopus laevis oocytes expressing Shaker channels with fast inactivation removed. Estimates of the forward and backward rates for transitions are obtained by fitting exponentials to macroscopic ionic and gating current relaxations at voltage extremes, where...
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