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Article

A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice.

Scandinavian journal of immunology - 1 Dec 2007

Nakatani K, Qu W-M, Zhang M-C, Fujii H, Furukawa H, Miyazaki T, Iwano M, Saito Y, Nose M, Ono M

Abstract excerpt

Aging readily affects immune system under the influence of environmental and/or intrinsic factors while accelerating the development of various immune disorders including autoimmune diseases. Little is known about molecular and cellular mechanisms connecting between immune senescence and development of autoimmune diseases. Here, we first show strain-specific and aging-sensitive onset of B-cell abnormality in a...

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Source

Identifiers

PMID: 17983422
DOI: 10.1111/j.1365-3083.2007.02020.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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