Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.

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Article

Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.

The Journal of biological chemistry - 5 Apr 1992

Cheatham B, Kahn C R

Abstract excerpt

We have investigated the structural and functional properties of two mutant insulin receptors in which Cys647 and Cys682,683,685 have been replaced with Ser (IRS647 and IRS682,683,685, respectively). Compared with the wild-type receptor (IRWT), both mutant receptors displayed altered sensitivities to dithiothreitol with respect to insulin binding and reduction of oligomeric forms. Subunit composition of the...

Topics

Affinity Labels
Animals
Base Sequence
CHO Cells
Cricetinae
Cross-Linking Reagents
Cysteine
DNA
Dithiothreitol
Electrophoresis, Polyacrylamide Gel
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Iodine Radioisotopes

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Phosphorylation

Precipitin Tests

Receptor, Insulin

Source

Open in PubMed

Identifiers

PMID: 1551916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1551916-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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