CCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates.

doi:10.1128/jvi.76.6.3059-3064.2002

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Article

CCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates.

Journal of virology - 1 Mar 2002

Thompson Daniah A D, Cormier Emmanuel G, Dragic Tatjana

Abstract excerpt

CCR5 and CXCR4 usage has been studied extensively with a variety of clade B human immunodeficiency virus type 1 (HIV-1) isolates. The determinants of CCR5 coreceptor function are remarkably consistent, with a region critical for fusion and entry located in the CCR5 amino-terminal domain (Nt). In particular, negatively charged amino acids and sulfated tyrosines in the Nt are essential for gp120 binding to CCR5....

Topics

Amino Acid Sequence
HIV Envelope Protein gp120
HIV Infections
HIV-1
Humans
Molecular Sequence Data
Mutation
Receptors, CCR5
Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 11861874
DOI: 10.1128/jvi.76.6.3059-3064.2002
PMCID: PMC135972

Genes

CCR5
CXCR4

Provenance

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