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Article

Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association.

Neurobiology of disease - 1 Jan 1997

Malafosse A, Leboyer M, d'Amato T, Amadéo S, Abbar M, Campion D, Canseil O, Castelnau D, Gheysen F, Granger B, Henrikson B, Poirier M F, Sabaté O, Samolyk D, Feingold J, Mallet J

Abstract excerpt

Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI). This possibility was further investigated by both parametric (lod score) and nonparametric (affected-pedigree-member and a case-control study) methods of analysis in 11 French MDI families and in a sample of 200 unrelated subjects. Both types of analyses corroborate the...

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Identifiers

PMID: 9440122
DOI: 10.1006/nbdi.1997.0149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association.PMID 9440122Read ↗

Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder.Semantic proximity Read ↗

A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.Semantic proximity Read ↗

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