Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11.

doi:10.1176/ajp.151.1.102

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Article

Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11.

The American journal of psychiatry - 1 Jan 1994

De bruyn A, Mendelbaum K, Sandkuijl L A, Delvenne V, Hirsch D, Staner L, Mendlewicz J, Van Broeckhoven C

Abstract excerpt

OBJECTIVE: Previous linkage and allelic association studies using DNA polymorphisms, cosegregation of cytogenetic abnormalities with psychiatric illness, and assignment of genes involved in neutotransmitter metabolism suggested that chromosome 11 may harbor a gene predisposing to bipolar illness....

Topics

Adolescent
Adult
Alleles
Bipolar Disorder
Child
Chromosomes, Human, Pair 11
Depressive Disorder
Family
Female
Genetic Linkage
Humans
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Models, Genetic

Monophenol Monooxygenase

Phenotype

Psychotic Disorders

Source

Open in PubMed

Identifiers

PMID: 7903509
DOI: 10.1176/ajp.151.1.102

Genes

DRD4
DRD2
HRAS
INS
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7903509-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11.PMID 7903509Read ↗

Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees.Semantic proximity Read ↗

A genetic linkage study of bipolar disorder and 13 markers on chromosome 11 including the D2 dopamine receptor.Semantic proximity Read ↗

Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder.Semantic proximity Read ↗

Genetic linkage mapping for a susceptibility locus to bipolar illness: chromosomes 2, 3, 4, 7, 9, 10p, 11p, 22, and Xpter.Semantic proximity Read ↗

Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X.Semantic proximity Read ↗

Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.Semantic proximity Read ↗

Progress and pitfalls: bipolar molecular linkage studies.Semantic proximity Read ↗

Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.Semantic proximity Read ↗

Possible locus for bipolar disorder near the dopamine transporter on chromosome 5.Semantic proximity Read ↗

Linkage of mood disorders with D2, D3 and TH genes: a multicenter study.Semantic proximity Read ↗

A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11.Semantic proximity Read ↗

Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series.Semantic proximity Read ↗

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