Article
Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees.
The American journal of psychiatry - 1 Feb 1996
Smyth C, Kalsi G, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P, Sherrington R, Petursson H, Gurling H
Abstract excerpt
OBJECTIVE: This study was undertaken to confirm or refute previous reports that link bipolar affective disorder to polymorphic DNA markers at or near the gene for tyrosine hydroxylase. METHOD: A previous linkage analysis, which used a tetranucleotide repeat polymorphism at the tyrosine hydroxylas...
Topics
- Alleles
- Bipolar Disorder
- Chromosomes, Human, Pair 11
- Depressive Disorder
- Genetic Linkage
- Humans
- Likelihood Functions
- Lod Score
- Microsatellite Repeats
- Models, Genetic
- Pedigree
- Tyrosine 3-Monooxygenase
- United Kingdom