Article
Rearrangement, hypermutation, and possible preferential use of a VH5 gene, VH32, in a Hodgkin's cell line.
Hematopathology and molecular hematology - 1 Jan 2000
Messineo C, Coupland R, Bakhshi A, Raffeld M, Irving S G, Bagg A, Cossman J
Abstract excerpt
Nonrandom use of immunoglobulin variable (V) gene segments is a feature of some B-cell neoplasms, possibly as a consequence of antigen selection. In Hodgkin's disease, the primary tissues, cell lines, and even single Reed-Sternberg cells can carry immunoglobulin gene rearrangements. Here, we exam...
Topics
- Base Sequence
- Cloning, Molecular
- Gene Rearrangement
- Genes, Immunoglobulin
- Hodgkin Disease
- Humans
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Tumor Cells, Cultured