Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.

doi:10.1084/jem.177.4.1039

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Article

Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.

The Journal of experimental medicine - 1 Apr 1993

Rassenti L Z, Kipps T J

Abstract excerpt

B cell chronic lymphocytic leukemia (CLL) is a malignancy of the CD5+ B cells. Prior studies indicated that CLL B cells generally express immunoglobulin (Ig) VH and VL genes with little or no somatic mutations. However, a recent report indicated that VH251, one of three VH genes belonging to the...

Topics

Adult
Aged
Amino Acid Sequence
Antigens, CD
B-Lymphocytes
Base Sequence
Blotting, Southern
CD5 Antigens
DNA, Neoplasm
Female
Flow Cytometry
Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Leukemia, Lymphocytic, Chronic, B-Cell

Male

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 7681468
DOI: 10.1084/jem.177.4.1039
PMCID: PMC2190987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7681468-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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