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Article

Two V(H)5 family genes expressed by human peripheral B cells display differential mutational frequencies in the V(H) region.

Molecular immunology - 1 Sept 2002

Chong Yong, Ikematsu Hideyuki, Murata Masayuki, Yamaji Kouzaburo, Nabeshima Shigeki, Kashiwagi Seizaburo, Hayashi Jun

Abstract excerpt

The heavy chain variable segment gene (V(H))5 family, one of the seven immunoglobulin (Ig) V(H) families, contains two functional genes, VH251 and VH32. To investigate functional differences between these V(H)5 family genes, V(H) segments expressed by human peripheral B cells were sequenced and analyzed. One hundred fifty-three sequences with unique V(H)DJ(H) recombinations were obtained from 17 adults. The...

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PMID: 12213325
DOI: 10.1016/s0161-5890(02)00054-8

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