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Article

DNA methylation alterations in urothelial carcinoma

1 Aug 2006

Abstract excerpt

In urothelial cancer, hypermethylation of specific genes and genome-wide hypomethylation, reflected in decreased methylation of LINE-1 retrotransposons, have both been reported, but were never investigated in the same specimens. We analyzed hypermethylation of six genes by methylation-specific PCR and LINE-1 hypomethylation by Southern blotting in 96 carcinoma tissues. Hypermethylation frequencies were: SFRP1...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 16775427
DOI: 10.4161/cbt.5.8.2885

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