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DNA HYPERMETHYLATION ON MULTIPLE CpG ISLANDS ASSOCIATED WITH INCREASED DNA METHYLTRANSFERASE DNMT1 PROTEIN EXPRESSION DURING MULTISTAGE UROTHELIAL CARCINOGENESIS

1 Apr 2005

Abstract excerpt

PURPOSE: We elucidated the significance of aberrant DNA methylation on multiple CpG islands and its correlation with DNA methyltransferase DNMT1 protein expression during urothelial carcinogenesis. MATERIALS AND METHODS: We examined the DNA methylation status on multiple CpG islands by methylation specific polymerase chain reaction and combined bisulfite restriction enzyme analysis in 12 specimens of normal...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 15821584
DOI: 10.1097/01.ju.0000154632.11824.4d

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