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Article

FGFs, their receptors, and human limb malformations: clinical and molecular correlations.

American journal of medical genetics - 15 Oct 2002

Wilkie Andrew O M, Patey Susannah J, Kan Shih-Hsin, van den Ouweland Ans M W, Hamel Ben C J

Abstract excerpt

Fibroblast growth factors (FGFs) comprise a family of 22 distinct proteins with pleiotropic signaling functions in development and homeostasis. These functions are mediated principally by four fibroblast growth factor receptors (FGFRs), members of the receptor tyrosine kinase family, with heparin glycosaminoglycan as an important cofactor. Developmental studies in chick and mouse highlight the critical role of...

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Source

Identifiers

PMID: 12357470
DOI: 10.1002/ajmg.10775

Genes

FGFR2
FGF10
FGF23
FGFR1
FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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