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Article

A Genetic Defect in β-Cell Gene Expression Segregates Independently From the fa Locus in the ZDF Rat

1 Jan 2001

Abstract excerpt

Type 2 diabetes is a strongly genetic disorder resulting from inadequate compensatory insulin secretion in the face of insulin resistance. The Zucker diabetic fatty (ZDF) rat is a model of type 2 diabetes and, like the human disease, has both insulin resistance (from a mutant leptin receptor causing obesity) and inadequate beta-cell compensation. To test for an independently inherited beta-cell defect, we...

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Identifiers

PMID: 11147796
DOI: 10.2337/diabetes.50.1.63

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Genetic Defect in β-Cell Gene Expression Segregates Independently From the fa Locus in the ZDF RatPMID 11147796Read ↗

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