Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.

doi:10.1007/s00441-004-1019-y

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Article

Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.

Cell and tissue research - 1 Feb 2005

Garris David R, Garris Bryan L

Abstract excerpt

The diabetes (db/db) genotype mutation induces a hyperglycemic-hyperinsulinemic endometabolic state in C57BL/KsJ mice, manifesting a type 2 NIDDM diabetes-obesity syndrome (DOS) in this hyperphagic, leptin receptor (lf) defective model. The severity of the DOS induced by the single gene, homozygous-recessive mutation may be therapeutically moderated by gonadal steroids and pre-steroidal metabolites. The current...

Topics

Acetyl-CoA Carboxylase
Animals
Atrophy
Autoradiography
Blood Glucose
Body Weight
Cell Nucleus
Diabetes Mellitus, Type 2
Estradiol
Female
Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocytochemistry

Homozygote

Hyperglycemia

Hyperinsulinism

Hyperlipidemias

Injections, Subcutaneous

Insulin

Source

Open in PubMed

Identifiers

PMID: 15654653
DOI: 10.1007/s00441-004-1019-y

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