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Article

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.

Science (New York, N.Y.) - 16 Feb 1996

Chua S C, Chung W K, Wu-Peng X S, Zhang Y, Liu S M, Tartaglia L, Leibel R L

Abstract excerpt

Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of...

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Identifiers

PMID: 8584938
DOI: 10.1126/science.271.5251.994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.PMID 8584938Read ↗

[The "diabetes" (db) gene of the mouse codes for a mutated leptin receptor--a cue to understanding obesity?].Semantic proximity Read ↗

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.Semantic proximity Read ↗

[The research applications of db/db mouse].Semantic proximity Read ↗

Abnormal splicing of the leptin receptor in diabetic mice.Semantic proximity Read ↗

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.Semantic proximity Read ↗

Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice.Semantic proximity Read ↗

Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat.Semantic proximity Read ↗

Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).Semantic proximity Read ↗

Metabolic characterization of a mouse deficient in all known leptin receptor isoforms.Semantic proximity Read ↗

[The hormone leptin reduces body weight. A mutant gene makes the mouse obese].Semantic proximity Read ↗

Defective STAT signaling by the leptin receptor in diabetic mice.Semantic proximity Read ↗

Molecular mapping of the mouse db mutation.Semantic proximity Read ↗

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