Article
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.
Science (New York, N.Y.) - 16 Feb 1996
Chua S C, Chung W K, Wu-Peng X S, Zhang Y, Liu S M, Tartaglia L, Leibel R L
Abstract excerpt
Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a s...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Chromosome Mapping
- Cloning, Molecular
- DNA Mutational Analysis
- Diabetes Mellitus
- Genetic Markers
- Leptin
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Molecular Sequence Data
- Obesity
- Phenotype
- Polymerase Chain Reaction
- Proteins