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Article

A family of human receptors structurally related to <i>Drosophila</i> Toll

20 Jan 1998

Abstract excerpt

The discovery of sequence homology between the cytoplasmic domains of Drosophila Toll and human interleukin 1 receptors has sown the conviction that both molecules trigger related signaling pathways tied to the nuclear translocation of Rel-type transcription factors. This conserved signaling scheme governs an evolutionarily ancient immune response in both insects and vertebrates. We report the molecular cloning...

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PMID: 9435236
DOI: 10.1073/pnas.95.2.588

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