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Article

Toll receptors: an expanding role in our understanding of human disease

1 Jun 2000

Abstract excerpt

Toll receptor proteins in Drosophila are involved in establishing the dorsal-ventral axis in embryogenesis as well as participating in the innate immune response to invading pathogens. The basic mediators of this response show striking similarities in plants, insects, and vertebrates. The cytoplasmic signaling cascade is exemplified by the human interleukin-1 receptor complex (IL-1R), resulting in transcriptional...

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PMID: 10857847
DOI: 10.1002/jlb.67.6.767

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