Article
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
Nature - 24 Jul 1997
Medzhitov R, Preston-Hurlburt P, Janeway C A
Abstract excerpt
Induction of the adaptive immune response depends on the expression of co-stimulatory molecules and cytokines by antigen-presenting cells. The mechanisms that control the initial induction of these signals upon infection are poorly understood. It has been proposed that their expression is controlled by the non-clonal, or innate, component of immunity that preceded in evolution the development of an adaptive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.