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Article

Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes

1 Apr 2000

Abstract excerpt

Toll is a Drosophila gene essential for ontogenesis and antimicrobial resistance. Several hortologues of Toll have been identified and cloned in vertebrates, namely Toll-like receptors (TLR). Human TLR are a growing family of molecules involved in innate immunity. TLR are structurally characterized by a cytoplasmic Toll/interleukin-1R (TIR) domain and by extracellular leucine-rich repeats. TLR characterized so...

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PMID: 10770275
DOI: 10.1002/jlb.67.4.450

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