Article
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.
Arthritis and rheumatism - 1 Jan 1998
Mudgett J S, Hutchinson N I, Chartrain N A, Forsyth A J, McDonnell J, Singer I I, Bayne E K, Flanagan J, Kawka D, Shen C F, Stevens K, Chen H, Trumbauer M, Visco D M
Abstract excerpt
OBJECTIVE: It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the arthritic paws of stromelysin 1 (SLN1)-deficient mice for loss of cartilage and for generation of neoepitopes that would be indicative of aggrecan cleavage. METHODS:...
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