Article
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Molecular and cellular biology - 1 Sept 2007
Wagenaar-Miller Rebecca A, Engelholm Lars H, Gavard Julie, Yamada Susan S, Gutkind J Silvio, Behrendt Niels, Bugge Thomas H, Holmbeck Kenn
Abstract excerpt
Collagen degradation is essential for cell migration, proliferation, and differentiation. Two key turnover pathways have been described for collagen: intracellular cathepsin-mediated degradation and pericellular collagenase-mediated degradation. However, the functional relationship between these two pathways is unclear and even controversial. Here we show that intracellular and pericellular collagen turnover...
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