Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of a novel aggrecan‐degrading activity in cartilage: Studies of mice deficient in both ADAMTS‐4 and ADAMTS‐5

31 May 2008

Abstract excerpt

OBJECTIVE: To characterize aggrecan catabolism and the overall phenotype in mice deficient in both ADAMTS-4 and ADAMTS-5 (TS-4/TS-5 Delta-cat) activity. METHODS: Femoral head cartilage from the joints of TS-4/TS-5 Delta-cat mice and wild-type mice were cultured in vitro, and aggrecan catabolism was stimulated with either interleukin-1alpha (IL-1alpha) or retinoic acid. Total aggrecan release was measured, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Complement system in diseases
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18512787
DOI: 10.1002/art.23458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of a novel aggrecan‐degrading activity in cartilage: Studies of mice deficient in both ADAMTS‐4 and ADAMTS‐5PMID 18512787Read ↗

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Semantic proximity Read ↗

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.Semantic proximity Read ↗

Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.Semantic proximity Read ↗

Transcriptomics of Wild‐Type Mice and Mice Lacking ADAMTS‐5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage DestructionSemantic proximity Read ↗

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.Semantic proximity Read ↗

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS FamilySemantic proximity Read ↗

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.Semantic proximity Read ↗

The role of ADAMTSs in arthritisSemantic proximity Read ↗

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.Semantic proximity Read ↗

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.Semantic proximity Read ↗

Extracellular matrix and pathogenic mechanisms in osteoarthritis.Semantic proximity Read ↗

Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.